Prognosis of Pleural Mesothelioma

Prognosis of Pleural Mesothelioma
Prognosis of Pleural Mesothelioma
Throughout the diagnostic process, doctors analyze the expected course and outcome for the disease—known as your prognosis. Providing an accurate prognosis challenges doctors because the disease is so complex, and each person responds differently to treatment.

The most important factor in a pleural mesothelioma prognosis is the stage of the disease at diagnosis. Staging is how doctors describe cancer's progression. An early-stage cancer offers a better chance of long-term survival than a late-stage cancer.

Patients in otherwise good health who can still perform normal daily tasks tend to respond better to treatment—another significant factor for survival.

The makeup, or histology, of a mesothelioma cancer cell greatly influences prognosis.

Among the subtypes of this disease, epithelial mesothelioma represents the majority of cases and is associated with the longest survival. Patients with this type respond best to treatment and typically live at least one year. Those with sarcomatoid and biphasic subtypes of mesothelioma have shorter survival rates, usually around six or eight months.

Sarcomatoid cells are the most aggressive mesothelioma cells in terms of rapid growth and resistance to treatments such as chemotherapy. Biphasic mesothelioma is a mix of epithelial and sarcomatoid cells. The ratio of both cells determines how a biphasic patient responds to treatment and how long they live. A higher ratio of epithelial cells translates into a longer survival time for the patient.

Other important prognostic factors include your age, sex and smoking history. Generally speaking, survival rates are higher for female patients, nonsmokers and patients younger than 55.

If doctors find cancer in fluid around the lungs, life expectancy is impacted. Cancerous pleural effusions are associated with shorter survival. Treatment with surgery or chemotherapy may extend survival for these patients.
Stage of disease at diagnosisCell subtype
Age of patient
Gender of patient
Patient's smoking history
Amount of fluid in the chest
Patient’s activity level
Cancer recurrence

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